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Title: [A meta-analysis on the association between genetic polymorphisms of osteoprotegerin and cardiovascular disease].
Author: Xin JY, Cong HL.
Journal: Zhonghua Xin Xue Guan Bing Za Zhi; 2018 Jun 24; 46(6):485-492. PubMed ID: 29925187.
Abstract:
Objective: To explore the association between genetic polymorphisms of rs2073617T/C (950T/C) and rs2073618G/C(1181G/C) in the osteoprotegerin gene and cardiovascular disease with meta-analysis. Methods: A computer-based search for the study of relationship between genetic polymorphisms of rs2073617T/C and rs2073618G/C in the osteoprotegerin gene and cardiovascular disease were performed in electronic databases including China National Knowledge Infrastructure(CNKI), China Biomedical Literature Database, Wanfang Database, Chinese Journal Full-text Database, Embase, PubMed, and Cochrane Library, supplemented by manual search, from the beginning of library to February 28, 2017. The quality of the included studies were assessed by the Newcastle-Ottawa Scale (NOS) scoring system. Data were analyzed using STATA 12.0 software. Results: Eleven clinical case-control studies that enrolled 2 115 patients with cardiovascular disease and 1 467 healthy subjects were included.The results indicated that osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C might be closely associated with the susceptibility to cardiovascular disease(rs2073617T/C allele model: OR=0.79, 95%CI 0.73-0.87, P=0.001;rs2073618G/C M allele and W allele: OR=0.83, 95%CI 0.74-0.92, P=0.001). The osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C were significantly related to the incidence of coronary artery disease and acute coronary syndrome(coronary artery disease allele model: OR=0.83, 95%CI 0.75-0.92, P=0.001; acute coronary syndrome allele model: OR=0.73, 95%CI 0.62-0.85, P<0.001). However, there was no significant correlation between the genetic polymorphisms of these two sites and the lesion vessel number of coronary artery (rs2073617T/C allele model:OR=1.00, 95%CI 0.81-1.24, P=0.985;rs2073618G/C allele model:OR=0.98, 95%CI 0.80-1.21, P=0.626). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-ligase detection reaction(PCR-LDR) evidenced the association between osteoprotegerin gene polymorphisms and cardiovascular disease(allele model: OR=0.79, 95%CI 0.72-0.86, P<0.001), but no obvious relationship was found with fluorogenic quantitative detection and molecularprobe(allele model: OR=0.86, 95%CI 0.65-1.12, P=0.263). Conclusion: This meta-analysis indicates that the osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C may be closely related to the increased risk of cardiovascular disease. 目的： 应用荟萃分析探讨骨保护素基因rs2073617T/C（950T/C）和rs2073618G/C（1181G/C）位点基因多态性与心血管疾病易患性的关系。 方法： 应用计算机检索并辅以手工检索，纳入从建库至2017年2月28日中国知网、中国生物医学文献数据库、万方数据库、中国期刊全文数据库、Embase、PubMed和Cochrane Library中关于骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与心血管疾病遗传关联性的观察性研究。采用Newcastle-Ottawa Scale（NOS）评分系统评价纳入研究的质量，采用STATA 12.0软件进行数据分析。 结果： 纳入了临床病例对照研究11项，包含心血管疾病患者2 115例和健康对照者1 467名。荟萃分析表明，骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与心血管疾病易患性相关（rs2073617T/C等位基因模型：OR=0.79，95%CI 0.73~0.87，P=0.001；rs2073618G/C等位基因模型：OR=0.83，95%CI 0.74~0.92，P=0.001）。骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与冠心病和急性冠状动脉综合征发病均相关（冠心病等位基因模型: OR=0.83, 95%CI 0.75~0.92，P=0.001；急性冠状动脉综合征等位基因模型：OR=0.73，95%CI 0.62~0.85，P<0.001）。这两个位点的基因多态性与冠状动脉病变支数均无相关性（rs2073617T/C等位基因模型：OR=1.00，95%CI 0.81~1.24，P=0.985；rs2073618G/C等位基因模型：OR=0.98，95%CI 0.80~1.21，P=0.626）。应用限制性片段长度多态性聚合酶链反应(PCR-RFLP)和聚合酶链反应-连接酶检测反应（PCR-LDR）方法发现骨保护素基因多态性与心血管疾病关联（等位基因模型：OR=0.79，95%CI 0.72~0.86，P<0.001），而荧光定量微测序法和分子探针技术未发现骨保护素基因多态性与心血管疾病关联（等位基因模型：OR=0.86，95%CI 0.65~1.12，P=0.263）。 结论： 荟萃分析表明，骨保护素基因rs2073617T/C与rs2073618G/C位点基因多态性可能与心血管疾病易患性相关。.

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