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  • Title: From Precise Slicing to General SHREDding: The Ubiquitin Ligase Ubr1 Roqs as a Multipurpose Protein Terminator.
    Author: Gardner RG, Ravid T.
    Journal: Mol Cell; 2018 Jun 21; 70(6):989-990. PubMed ID: 29932909.
    Abstract:
    In the current issue of Molecular Cell, Szoradi et al. (2018) present compelling data demonstrating how the newly identified SHRED pathway in yeast selectively shifts the E3 ligase Ubr1 specificity from N-end rule substrates to misfolded proteins in cells under proteostatic stress.
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