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  • Title: Design and synthesis of selenazole-substituted ritonavir analogs.
    Author: Qiao J, Zhao C, Liu J, Du Y.
    Journal: Bioorg Med Chem Lett; 2018 Aug 01; 28(14):2379-2381. PubMed ID: 29934245.
    Abstract:
    With the help of Surflex-Dock calculation, two ritonavir analogs in which one thioazole unit was replaced by selenazole have been designed and synthesized. The key selenazole structure was constructed from β-azido diselenide through a cascade diselenide cleavage/selenocarbonylation/Staudinger reduction/aza-Wittig reaction and a following MnO2 oxidation. The accordingly prepared compounds exhibited good anti-HIV-1 (IIIB) activities comparable to that of the original ritonavir, as well as the positive SI values.
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