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  • Title: The accessibility of phage MS2 RNA to structure specific nucleases in various conditions.
    Author: Grechko VV, Tymokhina GI, Aleshkina LA, Kalashnikova JI, Majev SP, Vassilenko SK.
    Journal: Mol Biol Rep; 1985 Apr; 10(3):137-42. PubMed ID: 2993849.
    Abstract:
    The accessibility of ds- and ss-segments of phage MS2 RNA to ds- and ss-specific nucleases (RNase III, nuclease SV and nuclease S1) was studied. The results show that the RNA has hydrolysis sites for all the nucleases used. These sites are unvariable in a wide range of the conditions (ionic strength, pH, bivalent cations and temperature) and are not changed also after denaturation-renaturation of the RNA. This testifies that the distribution and interactions of ds- and ss-segments in the whole molecule are very specific and stable.
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