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  • Title: [Rearrangement of the proto-oncogene c-myc in fresh cells from Burkitt's leukemia (L3)].
    Author: Mathieu-Mahul D, Bernheim A, Berger R, Mauchauffe M, Flandrin G, Larsen CJ.
    Journal: Nouv Rev Fr Hematol (1978); 1985; 27(3):157-61. PubMed ID: 2993997.
    Abstract:
    The presence of a rearrangement of the proto-oncogene c-myc was investigated in the DNA of fresh cells isolated from the blood of two patients with Burkitt's leukemia (L3), and from the node biopsy of a patient with Burkitt's lymphoma. Both samples from the L3 leukemia patients had the characteristic t(8;14) translocation, while the lymphoma specimen presented no abnormality of chromosome 8. Only one of the leukemic DNA's presented a rearranged c-myc pattern, with the breakpoint region located between the first and the second exon. The c-myc pattern of the two other patients appeared normal. The finding of a rearranged c-myc oncogene in fresh cells from a Burkitt's leukemia is direct evidence for the implication of c-myc in the disease whereas most of the rearrangements previously described have been found in cell lines established in culture.
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