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  • Title: Effect of parenteral vitamin D3 on plasma 25-hydroxyvitamin D3 concentration in sheep.
    Author: Smith BS, Wright H.
    Journal: Res Vet Sci; 1985 Jul; 39(1):59-61. PubMed ID: 2994190.
    Abstract:
    Vitamin D3 ranging in total amount from 10(5) iu (2.5 mg) to 9 X 10(5) iu (22.5 mg) was given intramuscularly either as a single injection or in three aliquots at three-weekly intervals to housed nonpregnant ewes on a vitamin D deficient diet. The effects on plasma concentrations of 25-hydroxyvitamin D3 (25-OHD3), the major metabolite of vitamin D, were monitored. The increase in plasma 25-OHD3 showed a large variation between animals and was related to, but not proportional to, the dose. None of the treatments produced 25-OHD3 concentrations greater than those in grazing sheep in summer. Repeated dosing provided for more efficient use of the injected vitamin D3.
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