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  • Title: Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
    Author: Gierek T, Lisiewicz J, Moszczyński P, Pilch J, Namysłowski G.
    Journal: Auris Nasus Larynx; 1985; 12(1):47-51. PubMed ID: 2994616.
    Abstract:
    Activity of N-acetyl-beta-D-glucosaminidase, beta-glucuronidase, and acid phosphatase and myeloperoxidase was determined in neutrophils and lymphocytes of patients with cancer of the larynx and precancerous states of the larynx as well as--for comparative reasons--in patients with malignant tumors of female generation organs, breast carcinoma, cancer of the stomach and endometriosis. The main result of investigations performed was in fact that intracellular deficiency of beta-glucuronidase within the neutrophils characterizes patients with cancer and precancerous states of the larynx. Patients with cancer of the larynx show additionally a deficiency of neutrophil myeloperoxidase. Deficiency of N-acetyl-beta-D-glucosaminidase occurs, in contrast, in patients with malignancies of female generation organ. Activity of myeloperoxidase in neutrophils from patients with gastric carcinoma is slightly elevated.
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