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  • Title: Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis.
    Author: Sobhan MR, Mahdinezhad-Yazdi M, Aghili K, Zare-Shehneh M, Rastegar S, Sadeghizadeh-Yazdi J, Neamatzadeh H.
    Journal: J Orthop; 2018 Sep; 15(3):747-753. PubMed ID: 29946197.
    Abstract:
    OBJECTIVE: A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA). METHODS: Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified. RESULTS: Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found. CONCLUSION: This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
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