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  • Title: Control of free cytoplasmic calcium by intracellular pH in rat lymphocytes.
    Author: Grinstein S, Goetz JD.
    Journal: Biochim Biophys Acta; 1985 Oct 10; 819(2):267-70. PubMed ID: 2994735.
    Abstract:
    Activation of Na+-H+ exchange in rat thymocytes was found to be followed by an increase in free cytoplasmic Ca2+ concentration [( Ca2+]i). We determined whether the change in [Ca2+]i was secondary to the uptake of Na+, or to the cytoplasmic alkalinization that result from activation of the antiport. Increasing intracellular [Na+] by treating the cells with ouabain or gramicidin failed to affect [Ca2+]i. In contrast, procedures that increased the cytoplasmic pH, such as addition of monensin or NH3, significantly elevated [Ca2+]i. These results suggest an important role of cytoplasmic pH in the control of [Ca2+]i in lymphocytes.
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