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  • Title: STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE.
    Author: Grechko OY, Shtareva DM, Spasov AA, Litvinov LA, Rashchenko AI.
    Journal: Eksp Klin Farmakol; 2016 Aug; 79(4):8-11. PubMed ID: 29949697.
    Abstract:
    We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.
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