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  • Title: Redox-dependent activation of 5'-nucleotidase in rat liver plasma membranes.
    Author: Tarakhovsky AM, Umansky VJ, Shlyakhovenko VA, Balitsky KP.
    Journal: FEBS Lett; 1985 Sep 23; 189(2):338-40. PubMed ID: 2995124.
    Abstract:
    Addition of NADH, but not NAD+ or NADPH, to rat liver plasma membranes resulted in the increase of their 5'-nucleotidase activity. NADH-dependent activation of 5'-nucleotidase was significantly suppressed by atebrine, an inhibitor of NADH dehydrogenase of plasma membranes, and completely abolished by 2,4-dinitrophenol (2 X 10(-4)M) and Triton X-100 (2%). Inhibitors of electron transfer in the mitochondrial respiratory chain, rotenone and potassium cyanide, failed to affect 5'-nucleotidase activity in both the presence and absence of NADH. The data obtained give reasons to suggest a redox-dependent mechanism of 5'-nucleotidase activation in rat liver plasma membranes.
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