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  • Title: [Functional interaction between alpha- and beta-adrenoreceptors of the small intestine].
    Author: Nesterova LA, Manukhin BN.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1985 Jul; 71(7):904-9. PubMed ID: 2995153.
    Abstract:
    Effect of desensitization of alpha-adrenoreceptors on the functional state of beta-receptors and vice versa was studied in isolated sections of the rat small intestine. Neither blockade, nor desensitization of alpha-receptors produced any effect on the sensitivity of beta-receptors to isopropyl-noradrenaline (IPN) whereas desensitization of beta-receptors to IPN resulted in the increase of alpha-receptors sensitivity to phenylephrine with a decreased maximal reaction. In the presence of GTP (0.02 mM) and propranolol (2.00 x 10(-7) M) IPN acts as a competitive reversible auto-inhibitor, GTP fully removing the inhibitory effect of IPN on both alpha- and beta-adrenoreceptors. Existence of functional interrelationship between alpha- and beta-adrenoreceptors is suggested.
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