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  • Title: Hypoxia induces autophagy in PA-l ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum.
    Author: Chen CD, Dai LN, Wang M, Lai XH, Wang J.
    Journal: Eur J Gynaecol Oncol; 2017; 38(2):277-281. PubMed ID: 29953795.
    Abstract:
    Pathological hypoxia exists in solid tumors and it creates a microenvironment for tumor cells which has a critical and complicated implication for cancer. Hypoxia can also activate autophagy which plays a dual role in cancer. In this study the authors analyzed the effect of hypoxia, the autophagy inhibitor 3-methyladenine (3-MA), cis-diamminedichloroplatinum (CDDP, cisplatin), and any combination of them on PA-l cells (a human ovarian cancer cell line) with a series of assays, focusing on autophagy induction, cell growth inhibition, and cell death by CDDP. CDDP caused apoptosis in normoxic PA-l cells and autophagy upon hypoxia treatment decreased apoptosis induction in hypoxic cells by CDDP, which has implications in cancer chemotherapy resistance.
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