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  • Title: Sulfonic acid enkephalin: binding specificity to rat brain opiate receptors.
    Author: Martin JL, Coletti-Previero MA, Roques BP, Descomps B.
    Journal: Neuropeptides; 1985 Jul; 6(4):293-302. PubMed ID: 2995863.
    Abstract:
    We tested sulfonic-acid enkephalin, a SO3H-Tyr derivative of the Leu-enkephalin, for its binding capacity to rat brain opiate receptors, by competition against several tritiated enkephalins. Using [3H]DADLE as the competitor, we demonstrated that sulfonic-acid enkephalin binds to rat brain opiate receptors, and using [3H]DSLET and [3H]DAGO as the competitors, we demonstrated that sulfonic-acid enkephalin binds preferentially to delta-opiate receptors. The affinity ratio of sulfonic-acid enkephalin for delta-opiate receptors versus mu-opiate receptors, is considerably higher than that of the parent compound, Leu-enkephalin, and of DADLE and is similar to the affinity ratio of DSLET for the same receptors.
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