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  • Title: From Dental to Mental Institutions: An American Dentist and a British Psychiatrist Highlight Insanity Following Nitrous-Oxide Administration.
    Author: Edwards ML, Bause GS.
    Journal: J Anesth Hist; 2018 Apr; 4(2):133-134. PubMed ID: 29960678.
    Abstract:
    In 1887, American dentist Samuel J. Hayes published reports associating unoxygenated anesthetics with asphyxia and insanity, and then British psychiatrist George H. Savage published a report of cases of insanity following nitrous-oxide anesthesia in British journals.
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