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  • Title: Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma.
    Author: Suen KC, Magee JF, Halparin LS, Chan NH, Greene CA.
    Journal: Acta Cytol; 1985; 29(5):867-72. PubMed ID: 2996274.
    Abstract:
    The major cytologic features seen in fine needle aspirates from two cases of fibrolamellar hepatocellular carcinoma were: liver-like tumor cells, characterized by plump, polygonal forms with eosinophilic, granular cytoplasm; large oval nuclei with extremely prominent solitary nucleoli; and parallel bands of fibrous tissue and fibrocytes seen within the tumor fragments. Other helpful features included intracytoplasmic hyaline globules and well-delineated pale bodies. Clinically, the tumors occurred in young patients with noncirrhotic livers and ran a more favorable course than do other types of hepatocellular carcinoma.
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