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  • Title: [Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats].
    Author: Kakorin PA, Babenkova IV, Teselkin YO, Ramenskaya GV, Demura TA, Kukes VG.
    Journal: Biomed Khim; 2018 Jun; 64(3):241-246. PubMed ID: 29964259.
    Abstract:
    The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation "Carcil". This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2¢-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata. Tsel'iu issledovaniia bylo izuchenie gepatoprotektornoĭ aktivnosti rasteniia Caragana jubata (Pall.) Poir. (karagana grivastaia) na modeli ostrogo gepatita, indutsirovannogo u krys Wistar vvedeniem atsetaminofena v doze 1000 mg/kg. Ustanovleno, chto vodnoe izvlechenie C. jubata proiavlialo vyrazhennoe gepatoprotektornoe deĭstvie, sopostavimoe s preparatom sravneniia “Karsil”. Éto proiavilos' normalizatsieĭ biokhimicheskikh pokazateleĭ krovi (alaninaminotransferazy, aspartataminotransferazy, shchelochnoĭ fosfatazy, kholesterina, obshchego bilirubina) i antioksidantnoĭ aktivnosti gomogenatov pecheni, kotoruiu opredeliali khemiliuminestsentnym metodom, osnovannym na okislenii liuminola, indutsirovannom 2,2¢-azobis(2-amidinopropanom). Pri gistologicheskom issledovanii vyiavlena normalizatsiia morfofunktsional'nykh pokazateleĭ pecheni krys, kotorye poluchali vodnoe izvlechenie karagany grivastoĭ.
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