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  • Title: Triptolide antagonized the cisplatin resistance in human ovarian cancer cell line A2780/CP70 via hsa-mir-6751.
    Author: Wang R, Ma X, Su S, Liu Y.
    Journal: Future Med Chem; 2018 Aug 01; 10(16):1947-1955. PubMed ID: 29966441.
    Abstract:
    AIM: We aimed to investigate the effect of triptolide on cisplatin resistance in ovarian cancer cell lines. METHODS: The apoptosis of ovarian cancer cell lines A2780 and A2780/CP70 was determined by flow cytometry. Protein expression levels of  Hexokinase 2 (HK2) were detected by western blot. Possible mRNAs which target HK 2 expression were predicted through online tools miRbase. RESULTS: Triptolide-promoted cell apoptosis of cisplatin-resistant ovarian cancer cell line A2780/CP70. Triptolide treatment sensitized the effect of cisplatin in A2780/CP70, as evidenced by decreased survival fraction of A2780/CP70 cells. Mechanically, triptolide treatment inhibited HK 2 expression in A2780/CP70 cells. In addition, Hsa-mir-6751 expression level was upregulated in A2780/CP70 cells after triptolide treatment.
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