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  • Title: A human c-src gene resides on the proximal long arm of chromosome 20 (cen----q131).
    Author: Sakaguchi AY, Mohandas T, Naylor SL.
    Journal: Cancer Genet Cytogenet; 1985 Oct; 18(2):123-9. PubMed ID: 2996754.
    Abstract:
    A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen----q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.
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