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  • Title: Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case.
    Author: Gomes MAF, Medeiros LLC, Lobo FPD, Wanderley NRS, Matos APR, Jácome TDN, Monteiro MGL, Luz KG.
    Journal: Rev Soc Bras Med Trop; 2018; 51(3):393-396. PubMed ID: 29972577.
    Abstract:
    Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
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