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  • Title: Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline.
    Author: Matsukawa H, Okabe E, Sakamoto H, Cho YW, Ito H.
    Journal: Jpn Circ J; 1978 Apr; 42(4):425-32. PubMed ID: 29976.
    Abstract:
    A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.
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