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  • Title: High-affinity angiotensin receptors in rat adrenal medulla.
    Author: Israel A, Niwa M, Plunkett LM, Saavedra JM.
    Journal: Regul Pept; 1985 Jul; 11(3):237-43. PubMed ID: 2997859.
    Abstract:
    Angiotensin II receptors have been quantitated in single rat adrenal medullas by incubation of tissue sections with 125I-[Sar1]-AII, autoradiography with exposure to 3H-sensitive Ultrofilm, computerized densitometry and comparison with 125I-labelled standards. Rat adrenal medulla contains a single class of high affinity AII receptors with a Ka of 0.84 +/- 0.02 X 10(9) M-1 and a Bmax of 3259 +/- 502 fmol/mg protein, one of the highest densities in AII receptors found in rat tissues. These observations provide evidence for a local site of action of AII in the release of adrenal medullary catecholamines.
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