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  • Title: Structure-activity relationships of atrial natriuretic factor (ANF). III. Correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells.
    Author: De Léan A, Thibault G, Seidah NG, Lazure C, Gutkowska J, Chrétien M, Genest J, Cantin M.
    Journal: Biochem Biophys Res Commun; 1985 Oct 15; 132(1):360-7. PubMed ID: 2998358.
    Abstract:
    The activity of various fragments of ANF as inhibitors of aldosterone secretion and as competitors of [125I] ANF (Arg101-Tyr126) binding to specific receptors was studied in bovine zona glomerulosa. Shortening or lengthening the N-terminal segment of ANF does not alter its biological activity while minimally altering affinity for its receptor. Removal of the C-terminal to Cys121 or expansion up to Arg128 leads to 1000-fold decrease in receptor affinity and activity. The results indicate the importance of the C-terminal segment of ANF in determining its active conformation.
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