These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells.
    Author: Kubota M, Moseley JM, Butera L, Dusting GJ, MacDonald PS, Martin TJ.
    Journal: Biochem Biophys Res Commun; 1985 Oct 15; 132(1):88-94. PubMed ID: 2998368.
    Abstract:
    In rat aortic smooth muscle cells in culture, calcitonin gene-related peptide stimulated cAMP formation in a dose-dependent manner, half-maximally effective at 0.5 to 1 nM. There was no effect on formation of cGMP, which was increased 300-fold in the same experiments by atriopeptin or sodium nitroprusside. The vasodilator effect of CGRP in rat aorta requires an intact endothelium, indicating that increase in vascular smooth muscle cAMP is not in itself sufficient to bring about relaxation. cAMP is probably a mediator of CGRP action in vascular smooth muscle.
    [Abstract] [Full Text] [Related] [New Search]