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Title: The mechanisms of action of noradrenaline on ouabain-sensitive rubidium uptake in guinea-pig myocardium. Author: Wanless RB, Noble MI, Drake-Holland AJ. Journal: Clin Sci (Lond); 1985 Dec; 69(6):737-43. PubMed ID: 2998691. Abstract: The mechanism by which noradrenaline stimulates ouabain-sensitive rubidium uptake in guinea-pig myocardial tissue has been studied. The stimulatory action of low concentrations of noradrenaline was reversed by high doses of propranolol (10(-5) mol/l) in atrial tissue, but was not reversed by alpha- or beta-, or combined alpha- and beta- adrenoceptor antagonists in ventricular tissue. Rubidium uptake was also found to increase with increasing extracellular potassium concentration [( K]o). The percentage values of stimulation by noradrenaline decreased with increasing [K]o. Noradrenaline had no effect on the rate of ATP splitting by an isolated membrane preparation of Na,K-ATPase. It is proposed that noradrenaline stimulates active cation transport by either (a) an effect secondary to increased passive efflux of K ions, or (b) an action at a novel adrenergic receptor, distinct from the ATPase enzyme itself.[Abstract] [Full Text] [Related] [New Search]