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  • Title: Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group.
    Author: Iijima Y, Nakagawa F, Handa S, Oda T, Naito A, Yamazaki M.
    Journal: FEBS Lett; 1985 Nov 18; 192(2):179-83. PubMed ID: 2998865.
    Abstract:
    Griseolic acid inhibited cAMP phosphodiesterase (PDE) at low concentrations, the I50 being of the order of 0.01-0.1 microM. Administration of griseolic acid to rats increased the cAMP level in liver and plasma several-fold. It increased glycogen degradation in mouse liver and stimulated lipolysis in isolated rat fat cells. Griseolic acid did not block the adenosine-elicited accumulation of cAMP in guinea pig brain slices. It had no effect on cAMP-dependent protein kinase from rat liver nor on the adenyl cyclase from rat brain.
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