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  • Title: delta 9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion.
    Author: Sakurai Y, Ohta H, Shimazoe T, Kataoka Y, Fujiwara M, Ueki S.
    Journal: Life Sci; 1985 Dec 09; 37(23):2181-5. PubMed ID: 2999542.
    Abstract:
    The present study was designed to examine the influence of delta 9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxy-dopamine. THC-induced ipsilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.
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