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  • Title: [Cytoreceptors in the molecular mechanisms of hormone action].
    Author: Rozen VB.
    Journal: Probl Endokrinol (Mosk); 1985; 31(5):21-6. PubMed ID: 2999760.
    Abstract:
    The author considered and analysed the phenomenological model of the functional-structural organization of a hormonal receptor molecule. He also defined the main types of hormone reception by target cells: intracellular and membranous. The paper presents some data on the structure and physicochemical characteristics of different hormone receptors, regularities and mechanisms of reception of steroid, thyroid and protein-peptide hormones (as well as catecholamines). Routes of the initiation of hormonal effects at the molecular level were shown. A special analysis was applied to the adenylate cyclase, calcium and protease routes of the initiation of hormonal effects from the cell surface. In conclusion uni- and multireceptor concepts of hormone multiple effects on cell metabolism were briefly defined.
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