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  • Title: In vitro insulin action on different ATPases of erythrocyte membranes in normal and diabetic rats.
    Author: Agarwal VR, Rastogi AK, Sahib MK, Sagar P.
    Journal: Acta Diabetol Lat; 1985; 22(2):111-8. PubMed ID: 3000116.
    Abstract:
    The in vitro effect of porcine insulin on Na+ + K+, Ca2+- and Mg2+-ATPases of the rat erythrocyte membrane of normal and alloxan-induced diabetic rats was investigated. Na+ + K+- and Ca2+-stimulated enzyme activities were significantly decreased in diabetic rats in comparison to normal animals. The specific activities of both these ATPases in the latter group were markedly reduced on pre-incubating the ghosts with insulin. Similar treatment of the erythrocyte membranes of diabetic animals, however, resulted in a significant increase of these activities. These qualitatively different effects of the hormone in the two groups increased progressively with hormone concentration and duration of pre-incubation. Mg2+-stimulated ATPase activity was not significantly affected in diabetes or by insulin.
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