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  • Title: Mitochondria "THE" target of myocardial conditioning.
    Author: Boengler K, Lochnit G, Schulz R.
    Journal: Am J Physiol Heart Circ Physiol; 2018 Nov 01; 315(5):H1215-H1231. PubMed ID: 30004243.
    Abstract:
    Several interventions, such as ischemic preconditioning, remote pre/perconditioning, or postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury. While several signal transduction pathways become activated by such maneuvers, they all have a common end point, namely, the mitochondria. These organelles represent an essential target of the cardioprotective strategies, and the preservation of mitochondrial function is central for the reduction of ischemia-reperfusion injury. In the present review, we address the role of mitochondria in the different conditioning strategies; in particular, we focus on alterations of mitochondrial function in terms of energy production, formation of reactive oxygen species, opening of the mitochondrial permeability transition pore, and mitochondrial dynamics induced by ischemia-reperfusion.
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