These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of Hydrogen Bond Acceptor Ability of Solvents on Molecular Self-Assembly of Sulfadiazine Solvates.
    Author: Zhang X, Wang C, Zhou L, Yang W, Zhou L, Bao Y, Zhang M, Hou B, Xu Z, Yin Q.
    Journal: J Pharm Sci; 2018 Nov; 107(11):2823-2828. PubMed ID: 30005983.
    Abstract:
    The solvate formation of sulfadiazine (SDZ) was systematically studied in the 4 selected solvents with the aids of experiment and simulation methods. The intermolecular interactions between solute and solvent molecules in different solid states were analyzed and compared through their single crystal structures, and the solution behavior of SDZ was discussed using molecular dynamics simulations. The results indicated that SDZ was easy to form solvates with the solvents having strong hydrogen bond acceptor ability, which determined the formation of hydrogen bonding synthon. Furthermore, the SDZ molecules conformation and packing were compared in various crystal structures. In addition, the desolvation processes of SDZ solvates were studied to investigate the role of solvent in different solvate structures.
    [Abstract] [Full Text] [Related] [New Search]