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Title: Interleukin 2 receptor blockade by anti-Tac antibody inhibits IFN-gamma induction. Author: Croll AD, Wilkinson MF, Morris AG. Journal: Cell Immunol; 1985 Apr 15; 92(1):184-9. PubMed ID: 3000625. Abstract: Anti-Tac antibody, which binds to the interleukin 2 (IL-2) receptor and thus blocks IL-2 binding to and activation of T lymphocytes, was used to investigate the role of IL-2 in interferon-gamma (IFN-gamma) production. Three T-cell mitogens (phytohemagglutinin, concanavalin A, and the pan-T monoclonal antibody OKT3) were used as IFN-gamma inducers. In each case, anti-Tac antibody clearly inhibited IFN-gamma production. This occurred even under conditions where cellular proliferation (as measured by incorporation of [3H]thymidine) was only slightly inhibited. The inhibitory effects of anti-Tac were reversed by the addition of purified IL-2. Therefore, endogenous production of IL-2 and its binding to the IL-2 receptor are needed for maximum IFN-gamma production.[Abstract] [Full Text] [Related] [New Search]