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  • Title: Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes.
    Author: Ebstein RP, Steinitz M, Mintzer J, Lipshitz I, Stessman J.
    Journal: Experientia; 1985 Dec 15; 41(12):1552-4. PubMed ID: 3000812.
    Abstract:
    Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of 125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down-regulation.
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