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  • Title: [Synthesis of virus-specific and cellular proteins in the presence of bonafton].
    Author: Gerasina SF, Farashian VR, Fadeeva NI, Ugarova TIu.
    Journal: Farmakol Toksikol; 1985; 48(5):92-6. PubMed ID: 3000819.
    Abstract:
    Inhibition of the synthesis of virus-specific proteins of influenza A/WSN/33 virus in the cells of chick embryo fibroblasts and in continuous cells of dog embryonal kidney was discovered as was a negligible inhibition of the synthesis of cell proteins in the presence of an original synthetic antivirus drug bonaphthon. Experiments were made to attain selective inhibition of individual virus-specific proteins of influenza virus in these cultures. In model experiments in vitro in a cell-free protein-synthesizing system, bonaphthon was demonstrated to inhibit translation of RNA-virus of encephalomyocarditis on the virus template without affecting translation on the cell template of hemoglobin mRNA.
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