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  • Title: Ovine corticotropin-releasing hormone stimulation test in normal children.
    Author: Ross JL, Schulte HM, Gallucci WT, Cutler GB, Loriaux DL, Chrousos GP.
    Journal: J Clin Endocrinol Metab; 1986 Feb; 62(2):390-2. PubMed ID: 3001126.
    Abstract:
    We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 microgram/kg) to 21 normal boys and girls, aged 6-15 yr. CRH stimulated release of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 +/- 9.4 (SD) pg/ml and 14.3 +/- 3.6 micrograms/dl, respectively, in the girls, and 20.7 +/- 9.7 pg/ml and 16.6 +/- 3.3 micrograms/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did not differ between girls or boys, or between children and adults. Cortisol-binding globulin concentrations in plasma did not change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.
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