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  • Title: [Persistent (chronic active) Epstein-Barr virus infection and arthritis in childhood].
    Author: Schuchmann L, Neumann-Haefelin D.
    Journal: Monatsschr Kinderheilkd; 1985 Nov; 133(11):845-7. PubMed ID: 3001512.
    Abstract:
    Between 1981 und 1983 some 1300 patients with the primary diagnosis of juvenile chronic arthritis were admitted. In 9 of them a persistent EBV-infection was simultaneously evident. The course of disease was primarily systemic with the characteristic criteria: high septic intermittent fever, rheumatic exanthema, hepatosplenomegaly and lymphadenopathy. It is still unclear whether a replication of virus in the synovia or a precipiation of immune complexes is involved. A common cause for the persistent EBV-infection and arthritis via an immune-suppressive agent is possible.
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