These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture.
    Author: Delaissé JM, Eeckhout Y, Sear C, Galloway A, McCullagh K, Vaes G.
    Journal: Biochem Biophys Res Commun; 1985 Dec 17; 133(2):483-90. PubMed ID: 3002346.
    Abstract:
    A specific and potent synthetic inhibitor of mammalian tissue collagenase and related metallo-proteinases inhibits the collagen matrix resorption induced by parathyroid hormone (PTH) in cultured embryonic mouse calvaria. The inhibition is reversible, dose-dependent and virtually complete at 50 microM inhibitor concentration whereas that due to a less potent stereoisomer is much weaker. The PTH-enhanced secretion of calvarial lysosomal enzymes and the small spontaneous leakage of lactate dehydrogenase are not affected by the inhibitor. These results suggest that collagenase plays a critical role in bone resorption. Its role is discussed in relation to that of cysteine-proteinases that have also been implicated in this process.
    [Abstract] [Full Text] [Related] [New Search]