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  • Title: O-Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure-Function Study.
    Author: Capicciotti CJ, Mancini RS, Turner TR, Koyama T, Alteen MG, Doshi M, Inada T, Acker JP, Ben RN.
    Journal: ACS Omega; 2016 Oct 31; 1(4):656-662. PubMed ID: 30023486.
    Abstract:
    Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of O-aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.
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