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  • Title: [Cerebrovascular effects of met- and leu-enkephalins].
    Author: Mirzoian RS, Ragimov KhS, Gan'shina TS.
    Journal: Biull Eksp Biol Med; 1986 Jan; 101(1):42-4. PubMed ID: 3002518.
    Abstract:
    Met- and leu-enkephalines have a two-phase influence on the brain blood supply: initial short-term blood flow increase is replaced by the decrease of cerebral blood flow. Enkephalines are established to possess a pronounced depressive influence on neurogenic spasms of cerebral vessels and somatosympathetic and vasomotor reflex both under systemic administration and administration into brain lateral ventricles. Bicucullin has no effect on leuenkephaline action on cerebral circulation and its nervous control, while naloxone either removes or reduces the effects. Hence, opiate receptors take part in the realization of cerebrovascular effects of opioid peptides. The data obtained show the brain opioid system involvement in the regulation of brain circulation.
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