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  • Title: Basal forebrain neurons projecting to the rat frontoparietal cortex: electrophysiological and pharmacological properties.
    Author: Lamour Y, Dutar P, Rascol O, Jobert A.
    Journal: Brain Res; 1986 Jan 01; 362(1):122-31. PubMed ID: 3002548.
    Abstract:
    Neurons located in the ventromedial globus pallidus (nucleus basalis) and substantia innominata, that were antidromically driven by electrical stimulation of the frontoparietal cortex, were recorded in the urethane anesthetized rat. The basalocortical neurons (BCNs) were antidromically driven with latencies of 1.1-13.5 ms, giving conduction velocities of 0.6-6.8 m/s. Many BCNs had regular patterns of spontaneous discharge (mean spontaneous activity: 20 impulses/s). Most BCNs were not responsive to non-noxious peripheral somatic stimulation. BCNs were readily excited by the iontophoretic application of glutamate and strongly inhibited by GABA. Eighty-five percent of the BCNs could be excited by acetylcholine. They could also be excited by cholinergic agonists. Muscarinic agonists excited a higher proportion of BCNs than nicotinic agonists. Excitatory responses to acetylcholine, carbachol and muscarinic agonists were abolished by atropine.
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