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  • Title: Rat hypothalamic extract inhibits vasopressin-stimulated Na+-K+-ATPase activity in the rat renal medulla.
    Author: Pippard C, Baylis PH.
    Journal: Cell Biochem Funct; 1986 Jan; 4(1):25-9. PubMed ID: 3002655.
    Abstract:
    Arginine vasopressin stimulates Na+-K+-ATPase activity located in the rat thick ascending limb of Henle's loop. mammalian hypothalamus appears to produce a factor capable of inhibiting Na+-K+-ATPase activity in a variety of tissues. The effect of a purified rat hypothalamic extract with and without AVP on rat renal Na+-K+-ATPase activity was evaluated by a cytochemical technique. The hypothalamic extract alone failed to affect basal Na+-K+-ATPase activity throughout renal segments after 10 min exposure. Na+-K+-ATPase activity stimulated by AVP (1-10 fmol l-1) for 10 min was inhibited by rat hypothalamic extract over the concentration range 10(-7)-10(-3) U ml-1 in a dose-dependent manner. Complete inhibition of AVP-stimulated Na+-K+-ATPase activity occurred at a hypothalamic extract concentration of 10(-3) U ml-1. Only Na+-K+-ATPase activity located in the renal medullary thick ascending limb was influenced by the rat hypothalamic extract.
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