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  • Title: Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid.
    Author: Yunoki T, Miyakoshi A, Otsuka M, Hayashi A.
    Journal: Int Ophthalmol; 2019 Aug; 39(8):1703-1708. PubMed ID: 30027448.
    Abstract:
    PURPOSE: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. METHODS: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. RESULTS: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation. CONCLUSION: In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.
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