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  • Title: Viral DNA sequences detected in a hamster liposarcoma induced by bovine papillomavirus type 4.
    Author: Moar MH, Jarrett WF, O'Neil BW.
    Journal: J Gen Virol; 1986 Jan; 67 ( Pt 1)():187-90. PubMed ID: 3003234.
    Abstract:
    Following intradermal inoculation of bovine papillomavirus type 4 (BPV-4) into a Syrian hamster, a liposarcoma developed at the inoculation site 20 months later. The DNA of this tumour contained multiple copies of the BPV-4 genome which existed in a free unintegrated state. Unintegrated viral DNA and viral DNA isolated from virus particles from bovine alimentary tract papillomas revealed identical cleavage patterns with CpG methylation-resistant and -sensitive restriction enzymes: apparently there was no gross methylation of CpG sites in either case. The entire BPV-4 genome appeared to be represented in the tumour DNA.
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