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  • Title: [Role of active vitamin D3 metabolites in regulating calcium metabolism in rats during hypokinesia].
    Author: Sergeev IN, Afonin BV, Blazheevich NV, Morukov BV, Belakovskiĭ MS.
    Journal: Kosm Biol Aviakosm Med; 1985; 19(6):46-50. PubMed ID: 3003454.
    Abstract:
    The rats exposed to prolonged hypokinesia showed hypocalciemia, lower PTH and higher calcitonin concentrations in the serum, decreased calcium absorption in the small intestine, and a trend toward nephro- and arteriocalcinosis. Prophylactic administration of 24,25-hydroxy D3. 1,25-hydroxy D3 and their combinations enhanced calcium absorption and alleviated hypocalciemia. The changes in the hormonal regulation of calcium homeostasis can be viewed as a factor responsible for calcium metabolic disorders associated with hypokinesia.
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