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  • Title: [Effects of a morphine-clomipramine combination on a test of experimental analgesia].
    Author: Montastruc JL, Tran MA, Guiol C, Blanc M, Gaillard G, Cotonat J, Montastruc P.
    Journal: Rev Neurol (Paris); 1985; 141(10):669-71. PubMed ID: 3003869.
    Abstract:
    Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does not result from a peripheral pharmacokinetic mechanism but probably involves a central interaction between clomipramine and opiates pathways.
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