These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibition of reduction in the testicular weight by WR-2721 in relation to the body weight after whole-body gamma irradiation.
    Author: Bhartiya HC, Jaimala.
    Journal: Strahlenther Onkol; 1986 Jan; 162(1):68-70. PubMed ID: 3003944.
    Abstract:
    Male Swiss albino mice were irradiated with 60Co gamma rays at 3, 6 and 8 Gy dose levels in separate groups in the presence and absence of the radioprotective drug, WR-2721. The drug treated animals received intraperiotoneal injection of 400 mg/kg body weight aqueous solution (pH 6.2) of WR-2721. Animals were weighted and sacrificed at various post-irradiation intervals between day 1/4 to day 28. Testes were weighed for determining the testis/body weight ratios. The results indicated that testis/body weight ratio reduced after radiation exposure and the extent of this reduction depended on the dose of exposure. Injection of WR-2721 inhibited the body weight loss including the testicular mass loss after irradiation, as depicted by the significantly higher testis/body weight ratio in the drug pretreated animals.
    [Abstract] [Full Text] [Related] [New Search]