These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of adrenocorticotropic hormone on the biosynthesis of glycerolipid components in the rat liver].
    Author: Pitsin DG, Titov VN, Vasileva-Dimova MP, Sanfirova VM.
    Journal: Vopr Med Khim; 1985; 31(5):53-60. PubMed ID: 3004035.
    Abstract:
    Single administration of ACTH led to stimulation of synthesis of saturated and monoenic fatty acids in liver tissue as well as to their esterification with formation of triacyl glycerols. The hormone inhibited elongation and desaturation of fatty acids and decreased the formation of polyenic fatty acids in liver tissue. Cycloheximide alone or simultaneously with ACTH activated synthesis of unsaturated and monoenic fatty acids and stimulated the glycerophosphate shunt of triacyl glycerols synthesis. The tropic hormone activated glyceroneogenesis contributing to an increase in concentration of both alpha-glycerophosphate and long-chain fatty acids in hepatocytes; either ACTH or cycloheximide stimulated the triacyl glycerols synthesis via induction of the key enzymes by excess of the substrates. Consumption of acetyl-CoA, derived from labeled leucine, for biosynthesis of individual lipids was regulated by other mechanisms distinct from those involved in consumption of acetyl-CoA pool, derived from labelled acetate.
    [Abstract] [Full Text] [Related] [New Search]