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  • Title: Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.
    Author: Dryja TP, Rapaport JM, Epstein J, Goorin AM, Weichselbaum R, Koufos A, Cavenee WK.
    Journal: Am J Hum Genet; 1986 Jan; 38(1):59-66. PubMed ID: 3004203.
    Abstract:
    We provide evidence that some human osteosarcomas arise subsequent to the development of homozygosity at loci on the long arm of chromosome 13. The resulting chromosome 13q homozygosity allows the phenotypic expression of any recessive allele on that chromosome. Clinical evidence suggests that it is the retinoblastoma locus within 13q14 that is involved in the formation of these bone tumors.
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