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Title: Expression of aldolase A messenger RNAs in human adult and foetal tissues and in hepatoma. Author: Mennecier F, Daegelen D, Schweighoffer F, Levin M, Kahn A. Journal: Biochem Biophys Res Commun; 1986 Feb 13; 134(3):1093-100. PubMed ID: 3004482. Abstract: 3 specific cDNA clones for human aldolase A were isolated from a human muscle library. One of them was subcloned in M 13 phage, then used as a probe to investigate the patterns and the levels of aldolase A mRNA in various human tissues. Two mRNA species differing in length were observed. The lighter one -1550 bases- was found specific to skeletal muscle; its amount increased during muscle development. The heavier aldolase A mRNA -1650 bases- accounted for foetal and ubiquitous presence of aldolase A isozyme. The resurgence of aldolase A in hepatomas occurred through this latter mRNA species.[Abstract] [Full Text] [Related] [New Search]