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  • Title: Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.
    Author: Parravicini CL, Vago L, Costanzi GC, Gluckman JC, Klatzmann D, Berti E, Barre-Sinoussi F, Chermann JC, Lazzarin A, Moroni M.
    Journal: Boll Ist Sieroter Milan; 1985; 64(5):422-4. PubMed ID: 3004544.
    Abstract:
    This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.
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